One-Year Outcomes of the SAVE Study: Sirolimus as a Therapeutic Approach for UVEitis.

ABSTRACT:

Purpose

To determine the efficacy and safety of repeated intravitreal and subconjunctival administrations of sirolimus in patients with noninfectious uveitis at 1 year in the Sirolimus as a Therapeutic Approach UVEitis (SAVE) Study.

Methods

Open-label, prospective, and randomized interventional clinical trial in which 30 patients with noninfectious intermediate, posterior, or panuveitis were randomized 1:1 to receive sirolimus 352-μg intravitreal or 1320-μg subconjunctival. Sirolimus was administered at days 0, 60, and 120. At month 6, all subjects were allowed to receive sirolimus at intervals greater than or equal to 2 months and until month 12. Changes in vitreous haze (VH), visual acuity (VA), and retinal thickness at month 12 were compared with base

SUBMITTER: Ibrahim MA 

PROVIDER: S-EPMC4356037 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature