Caloric restriction protects against electrical kindling of the amygdala by inhibiting the mTOR signaling pathway.

ABSTRACT: Caloric restriction (CR) has been shown to possess antiepileptic properties; however its mechanism of action is poorly understood. CR might inhibit the activity of the mammalian or mechanistic target of rapamycin (mTOR) signaling cascade, which seems to participate crucially in the generation of epilepsy. Thus, we investigated the effect of CR on the mTOR pathway and whether CR modified epilepsy generation due to electrical amygdala kindling. The former was studied by analyzing the phosphorylation of adenosine monophosphate-activated protein kinase, protein kinase B and the ribosomal protein S6. The mTOR cascade is regulated by energy and by insulin levels, both of which may be changed by CR; thus we investigated if CR altered the levels of energy substrates in the blood or the level of in

SUBMITTER: Phillips-Farfan BV 

PROVIDER: S-EPMC4356078 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature