Association of sickle cell trait with chronic kidney disease and albuminuria in African Americans.

ABSTRACT:

Importance

The association between sickle cell trait (SCT) and chronic kidney disease (CKD) is uncertain.

Objective

To describe the relationship between SCT and CKD and albuminuria in self-identified African Americans.

Design, setting, and participants

Using 5 large, prospective, US population-based studies (the Atherosclerosis Risk in Communities Study [ARIC, 1987-2013; n = 3402], Jackson Heart Study [JHS, 2000-2012; n = 2105], Coronary Artery Risk Development in Young Adults [CARDIA, 1985-2006; n = 848], Multi-Ethnic Study of Atherosclerosis [MESA, 2000-2012; n = 1620], and Women's Health Initiative [WHI, 1993-2012; n = 8000]), we evaluated 15,975 self-identified African Americans (1248 participants with SCT [SCT carriers] and 14,727 participants without SCT [noncar

SUBMITTER: Naik RP 

PROVIDER: S-EPMC4356116 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature