Glucose-sensitive nanofiber scaffolds with an improved sensing design for physiological conditions.

ABSTRACT: Continuous physiological monitoring of electrolytes and small molecules such as glucose, creatinine, and urea is currently unavailable but achieving such a capability would be a major milestone for personalized medicine. Optode-based nanosensors are an appealing analytical platform for designing in vivo monitoring systems. In addition to the necessary analytical performance, such nanosensors must also be biocompatible and remain immobile at the implantation site. Blood glucose in particular remains a difficult but high-value analyte to monitor continuously. Previously, we developed glucose-sensitive nanosensors that measure glucose by a competitive binding mechanism between glucose and a fluorescent dye to 4-carboxy-3-fluorophenyl boronic acid. To improve the sensitivity and residency time

SUBMITTER: Balaconis MK 

PROVIDER: S-EPMC4356171 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature