Ontology highlight
ABSTRACT:
SUBMITTER: Anderson DM
PROVIDER: S-EPMC4356254 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Cell 20150129 4
Functional micropeptides can be concealed within RNAs that appear to be noncoding. We discovered a conserved micropeptide, which we named myoregulin (MLN), encoded by a skeletal muscle-specific RNA annotated as a putative long noncoding RNA. MLN shares structural and functional similarity with phospholamban (PLN) and sarcolipin (SLN), which inhibit SERCA, the membrane pump that controls muscle relaxation by regulating Ca(2+) uptake into the sarcoplasmic reticulum (SR). MLN interacts directly wit ...[more]