Clinical implications of insulin-like growth factor II mRNA-binding protein 3 expression in non-small cell lung carcinoma.

ABSTRACT: In order to examine the role of insulin-like growth factor II mRNA-binding protein 3 (IMP3) expression for the prognostic evaluation of non-small cell lung carcinoma (NSCLC), a total of 186 breast cancer patients, with adjacent non-tumor lung tissues, were selected for immunohistochemical staining of IMP3 protein. The NSCLC tissues and paired adjacent non-tumor tissues of six patients were quantified using reverse transcription quantitative polymerase chain reaction. The correlations between IMP3 overexpression and the clinical features of NSCLC were evaluated using the χ² test and Fisher's exact test. The survival rate was calculated using the Kaplan-Meier method, and the association between prognostic factors and patient survival was also analyzed by Cox's proportional hazards

SUBMITTER: Zhang J 

PROVIDER: S-EPMC4356331 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature