Ontology highlight
ABSTRACT:
SUBMITTER: Thakar J
PROVIDER: S-EPMC4356402 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Thakar Juilee J Mohanty Subhasis S West A Phillip AP Joshi Samit R SR Ueda Ikuyo I Wilson Jean J Meng Hailong H Blevins Tamara P TP Tsang Sui S Trentalange Mark M Siconolfi Barbara B Park Koonam K Gill Thomas M TM Belshe Robert B RB Kaech Susan M SM Shadel Gerald S GS Kleinstein Steven H SH Shaw Albert C AC
Aging 20150101 1
To elucidate gene expression pathways underlying age-associated impairment in influenza vaccine response, we screened young (age 21-30) and older (age≥65) adults receiving influenza vaccine in two consecutive seasons and identified those with strong or absent response to vaccine, including a subset of older adults meeting criteria for frailty. PBMCs obtained prior to vaccination (Day 0) and at day 2 or 4, day 7 and day 28 post-vaccine were subjected to gene expression microarray analysis. We def ...[more]