A highly accurate inclusive cancer screening test using Caenorhabditis elegans scent detection.

ABSTRACT: Early detection and treatment are of vital importance to the successful eradication of various cancers, and development of economical and non-invasive novel cancer screening systems is critical. Previous reports using canine scent detection demonstrated the existence of cancer-specific odours. However, it is difficult to introduce canine scent recognition into clinical practice because of the need to maintain accuracy. In this study, we developed a Nematode Scent Detection Test (NSDT) using Caenorhabditis elegans to provide a novel highly accurate cancer detection system that is economical, painless, rapid and convenient. We demonstrated wild-type C. elegans displayed attractive chemotaxis towards human cancer cell secretions, cancer tissues and urine from cancer patients but avoided contr

SUBMITTER: Hirotsu T 

PROVIDER: S-EPMC4356513 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature