Antibodies against immature virions are not a discriminating factor for dengue disease severity.

ABSTRACT: Humoral immunity plays an important role in controlling dengue virus (DENV) infection. Antibodies (Abs) developed during primary infection protect against subsequent infection with the same dengue serotype, but can enhance disease following secondary infection with a heterologous serotype. A DENV virion has two surface proteins, envelope protein E and (pre)-membrane protein (pr)M, and inefficient cleavage of the prM protein during maturation of progeny virions leads to the secretion of immature and partially immature particles. Interestingly, we and others found that historically regarded non-infectious prM-containing DENV particles can become highly infectious in the presence of E- and prM-Abs. Accordingly, we hypothesized that these virions contribute to the exacerbation of disease durin

SUBMITTER: Rodenhuis-Zybert IA 

PROVIDER: S-EPMC4356584 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature