Regulation of neuronal cav3.1 channels by cyclin-dependent kinase 5 (Cdk5).

ABSTRACT: Low voltage-activated (LVA) T-type Ca2+ channels activate in response to subthreshold membrane depolarizations and therefore represent an important source of Ca2+ influx near the resting membrane potential. In neurons, these proteins significantly contribute to control relevant physiological processes including neuronal excitability, pacemaking and post-inhibitory rebound burst firing. Three subtypes of T-type channels (Cav3.1 to Cav3.3) have been identified, and using functional expression of recombinant channels diverse studies have validated the notion that T-type Ca2+ channels can be modulated by various endogenous ligands as well as by second messenger pathways. In this context, the present study reveals a previously unrecognized role for cyclin-dependent kinase 5 (Cdk5) in the regula

SUBMITTER: Calderon-Rivera A 

PROVIDER: S-EPMC4356599 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature