Adjuvant therapy in lymph node-positive vulvar cancer: the AGO-CaRE-1 study.

ABSTRACT:

Background

Women with node-positive vulvar cancer have a high risk for disease recurrence. Indication criteria for adjuvant radiotherapy are controversial. This study was designed to further understand the role of adjuvant therapy in node-positive disease.

Methods

Patients with primary squamous-cell vulvar cancer treated at 29 gynecologic cancer centers in Germany from 1998 through 2008 were included in this retrospective exploratory multicenter cohort study. Of 1618 documented patients, 1249 had surgical groin staging and known lymph node status and were further analyzed. All statistical tests were two-sided.

Results

Four hundred forty-seven of 1249 patients (35.8%) had lymph node metastases (N+). The majority of N+ patients had one (172 [38.5%]) or two (102 [22.8%])

SUBMITTER: Mahner S 

PROVIDER: S-EPMC4356703 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature