RORA and posttraumatic stress trajectories: main effects and interactions with childhood physical abuse history.

ABSTRACT:

Background

Longitudinal studies of posttraumatic stress (PTS) have documented environmental factors as predictors of trajectories of higher, versus lower, symptoms, among them experiences of childhood physical abuse. Although it is now well-accepted that genes and environments jointly shape the risk of PTS, no published studies have investigated genes, or gene-by-environment interactions (GxEs), as predictors of PTS trajectories. The purpose of this study was to fill this gap.

Methods and materials

We examined associations between variants of the retinoid-related orphan receptor alpha (RORA) gene and trajectory membership among a sample of predominantly non-Hispanic Black urban adults (N = 473). The RORA gene was selected based on its association with posttraumatic stress di

SUBMITTER: Lowe SR 

PROVIDER: S-EPMC4356849 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature