Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder.

ABSTRACT:

Background

The immune system has been increasingly implicated in the development of mood and anxiety disorders. Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon (IKBKE) gene encodes IKKε protein that is involved in innate immunity, predominantly antiviral response generation. It also bears pro-inflammatory properties that could affect psychiatric outcomes. In order to investigate the possible role of IKBKE gene in major depressive disorder (MDD) and panic disorder (PD), we conducted a case-control genetic association study concerning these disorders.

Methods

In all, 14 SNPs of IKBKE gene were genotyped in groups of 391 patients with MDD and 190 patients with PD together with respective 389 and 371 healthy control individuals. The given groups wer

SUBMITTER: Traks T 

PROVIDER: S-EPMC4356867 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature