Peripherally increased artemin is a key regulator of TRPA1/V1 expression in primary afferent neurons.

ABSTRACT:

Background

Artemin, a member of the glial cell line-derived neurotrophic factor family, is known to have a variety of neuronal functions, and has been the subject of attention because it has interesting effects, including bi-directional results in modulation in neuropathic and inflammatory pain. It has been shown that the overexpression of artemin is associated with an increase in the expression of TRP family channels in primary afferents and subsequent hyperalgesia, and an increase in neuronal activity. The purpose of this study was to examine the peripheral synthesis of artemin in inflammatory and neuropathic pain models, and to demonstrate the effects of long-term or repeated application of artemin in vivo on pain behaviors and on the expression of TRP family channels. Further,

SUBMITTER: Ikeda-Miyagawa Y 

PROVIDER: S-EPMC4357199 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature