K-core decomposition of a protein domain co-occurrence network reveals lower cancer mutation rates for interior cores.

ABSTRACT:

Background

Network biology currently focuses primarily on metabolic pathways, gene regulatory, and protein-protein interaction networks. While these approaches have yielded critical information, alternative methods to network analysis will offer new perspectives on biological information. A little explored area is the interactions between domains that can be captured using domain co-occurrence networks (DCN). A DCN can be used to study the function and interaction of proteins by representing protein domains and their co-existence in genes and by mapping cancer mutations to the individual protein domains to identify signals.

Results

The domain co-occurrence network was constructed for the human proteome based on PFAM domains in proteins. Highly connected domains in the centra

SUBMITTER: Emerson AI 

PROVIDER: S-EPMC4357223 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature