Transcriptomal changes and functional annotation of the developing non-human primate choroid plexus.

ABSTRACT: The choroid plexuses are small organs that protrude into each brain ventricle producing cerebrospinal fluid that constantly bathes the brain. These organs differentiate early in development just after neural closure at a stage when the brain is little vascularized. In recent years the plexus has been shown to have a much more active role in brain development than previously appreciated thereby it can influence both neurogenesis and neural migration by secreting factors into the CSF. However, much of choroid plexus developmental function is still unclear. Most previous studies on this organ have been undertaken in rodents but translation into humans is not straightforward since they have a different timing of brain maturation processes. We have collected choroid plexus from three fetal gest

SUBMITTER: Ek CJ 

PROVIDER: S-EPMC4357249 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature