Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population.

ABSTRACT:

Objective

To investigate genetic and lifestyle factors and their interactions on plasma homocysteine (Hcy) concentrations in the Boston Puerto Rican population.

Design

Cross-sectional study. Plasma concentrations of Hcy, folate, vitamin B12 and pyridoxal phosphate were measured, and genetic polymorphisms were determined. Data on lifestyle factors were collected in interviews.

Setting

A population survey of health and nutritional measures.

Subjects

A total of 994 Puerto Rican men and women residing in the Boston metropolitan area.

Results

Smoking status was positively associated with plasma Hcy. Genetic polymorphisms MTHFR 677C→T, FOLH1 1561C→T, FOLH1 rs647370 and PCFT 928A→G interacted significantly with smoking for Hcy. MTHFR 1298A→C (P = 0·040) and PCF

SUBMITTER: Huang T 

PROVIDER: S-EPMC4357314 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature