The complex contributions of genetics and nutrition to immunity in Drosophila melanogaster.

ABSTRACT: Both malnutrition and undernutrition can lead to compromised immune defense in a diversity of animals, and "nutritional immunology" has been suggested as a means of understanding immunity and determining strategies for fighting infection. The genetic basis for the effects of diet on immunity, however, has been largely unknown. In the present study, we have conducted genome-wide association mapping in Drosophila melanogaster to identify the genetic basis for individual variation in resistance, and for variation in immunological sensitivity to diet (genotype-by-environment interaction, or GxE). D. melanogaster were reared for several generations on either high-glucose or low-glucose diets and then infected with Providencia rettgeri, a natural bacterial pathogen of D. melanogaster. Systemic p

SUBMITTER: Unckless RL 

PROVIDER: S-EPMC4357385 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature