VORFFIP-driven dock: V-D2OCK, a fast and accurate protein docking strategy.

ABSTRACT: The experimental determination of the structure of protein complexes cannot keep pace with the generation of interactomic data, hence resulting in an ever-expanding gap. As the structural details of protein complexes are central to a full understanding of the function and dynamics of the cell machinery, alternative strategies are needed to circumvent the bottleneck in structure determination. Computational protein docking is a valid and valuable approach to model the structure of protein complexes. In this work, we describe a novel computational strategy to predict the structure of protein complexes based on data-driven docking: VORFFIP-driven dock (V-D2OCK). This new approach makes use of our newly described method to predict functional sites in protein structures, VORFFIP, to define the

SUBMITTER: Segura J 

PROVIDER: S-EPMC4357426 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature