A randomised, double blind trial of N-Acetylcysteine for hearing protection during stapes surgery.

ABSTRACT:

Background

Otosclerosis is a disorder that impairs middle ear function, leading to conductive hearing loss. Surgical treatment results in large improvement of hearing at low sound frequencies, but high-frequency hearing often suffers. A likely reason for this is that inner ear sensory cells are damaged by surgical trauma and loud sounds generated during the operation. Animal studies have shown that antioxidants such as N-Acetylcysteine can protect the inner ear from noise, surgical trauma, and some ototoxic substances, but it is not known if this works in humans. This trial was performed to determine whether antioxidants improve surgical results at high frequencies.

Methods

We performed a randomized, double-blind and placebo-controlled parallel group clinical trial at three

SUBMITTER: Bagger-Sjoback D 

PROVIDER: S-EPMC4357436 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature