Telomere length in peripheral blood leukocytes and lung cancer risk: a large case-control study in Caucasians.

ABSTRACT: Telomere dysfunction is a crucial event in malignant transformation and tumorigenesis. Telomere length in peripheral blood leukocytes has been associated with lung cancer risk, but the relationship has remained controversial. In this study, we investigated whether the association might be confounded by study of different histological subtypes of lung cancer. We measured relative telomere lengths in patients in a large case-control study of lung cancer and performed stratified analyses according to the two major histologic subtypes [adenocarcinoma and squamous cell carcinoma (SCC)]. Notably, patients with adenocarcinoma had longer telomeres than controls, whereas patients with SCC had shorter telomeres compared with controls. Long telomeres were associated with increased risk of adenocarcin

SUBMITTER: Sanchez-Espiridion B 

PROVIDER: S-EPMC4357479 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature