Risk of neuropsychiatric adverse events associated with varenicline: systematic review and meta-analysis.

ABSTRACT:

Objective

To determine the risk of neuropsychiatric adverse events associated with use of varenicline compared with placebo in randomised controlled trials.

Design

Systematic review and meta-analysis comparing study effects using two summary estimates in fixed effects models, risk differences, and Peto odds ratios.

Data sources

Medline, Embase, PsycINFO, the Cochrane Central Register of Controlled Trials (CENTRAL), and clinicaltrials.gov.

Eligibility criteria for selecting studies

Randomised controlled trials with a placebo comparison group that reported on neuropsychiatric adverse events (depression, suicidal ideation, suicide attempt, suicide, insomnia, sleep disorders, abnormal dreams, somnolence, fatigue, anxiety) and death. Studies that did not involve hum

SUBMITTER: Thomas KH 

PROVIDER: S-EPMC4357491 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature