Positive association between serum silicon levels and bone mineral density in female rats following oral silicon supplementation with monomethylsilanetriol.

ABSTRACT:

Unlabelled

Observational (epidemiological) studies suggest the positive association between dietary silicon intake and bone mineral density may be mediated by circulating estradiol level. Here, we report the results of a silicon supplementation study in rats that strongly support these observations and suggest an interaction between silicon and estradiol.

Introduction

Epidemiological studies report strong positive associations between dietary silicon (Si) intake and bone mineral density (BMD) in premenopausal women and indicate that the association may be mediated by estradiol. We have tested this possibility in a mixed-gender rodent intervention study.

Methods

Tissue samples were obtained from three groups of 20-week-old Sprague Dawley rats (five males and five femal

SUBMITTER: Jugdaohsingh R 

PROVIDER: S-EPMC4357649 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature