Plasma lactate and incident hypertension in the atherosclerosis risk in communities study.

ABSTRACT:

Background

Recent evidence suggests that insufficient oxidative capacity or mitochondrial dysfunction may play a causal role in the development of high blood pressure. However, this hypothesis has not been tested in the general population. We hypothesized that lactate, a measure of oxidative capacity, would be positively associated with incident hypertension even after accounting for traditional hypertension risk factors.

Methods

Plasma lactate was measured in 5,554 participants from the Atherosclerosis Risk in Communities (ARIC) Study with no subclinical or diagnosed hypertension at baseline (1996-1998). Incident hypertension was defined by self-report or hypertension medication use. Analyses were performed with Cox proportional hazards models.

Results

The mean age w

SUBMITTER: Juraschek SP 

PROVIDER: S-EPMC4357800 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature