Lung cancer detectability by test, histology, stage, and gender: estimates from the NLST and the PLCO trials.

ABSTRACT:

Background

Implementing optimal lung cancer screening programs requires knowledge of the natural history and detectability of lung cancer. This information can be derived from the results of clinical trials with the aid of microsimulation models.

Methods

Data from the Surveillance, Epidemiology, and End Results (SEER) program and individual-level data from the National Lung Screening Trial (NLST) and the Prostate, Lung, Colon, and Ovarian Cancer Screening trial (PLCO) were used to investigate the sensitivity (by histology and stage) of CT and chest radiography (CXR) and the mean preclinical sojourn time (MPST) of lung cancer (by gender, histology, and stage). The MISCAN-Lung model was used to reproduce the lung cancer incidence by method of detection (clinically or screen-de

SUBMITTER: Ten Haaf K 

PROVIDER: S-EPMC4357842 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature