The cellobiose sensor CebR is the gatekeeper of Streptomyces scabies pathogenicity.

ABSTRACT:

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A relatively small number of species in the large genus Streptomyces are pathogenic; the best characterized of these is Streptomyces scabies. The pathogenicity of S. scabies strains is dependent on the production of the nitrated diketopiperazine thaxtomin A, which is a potent plant cellulose synthesis inhibitor. Much is known about the genetic loci associated with plant virulence; however, the molecular mechanisms by which S. scabies triggers expression of thaxtomin biosynthetic genes, beyond the pathway-specific activator TxtR, are not well understood. In this study, we demonstrate that binding sites for the cellulose utilization repressor CebR occur and function within the thaxtomin biosynthetic cluster. This was an unexpected result, as CebR is devoted to primary meta

SUBMITTER: Francis IM 

PROVIDER: S-EPMC4358012 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature