The proangiogenic effect of iroquois homeobox transcription factor Irx3 in human microvascular endothelial cells.

ABSTRACT: Angiogenesis is a dynamic process required for embryonic development. However, postnatal vascular growth is characteristic of multiple disease states. Despite insights into the multistep process in which adhesion molecules, extracellular matrix proteins, growth factors, and their receptors work in concert to form new vessels from the preexisting vasculature, there remains a lack of insight of the nuclear transcriptional mechanisms that occur within endothelial cells (ECs) in response to VEGF. Iroquois homeobox gene 3 (Irx3) is a transcription factor of the Iroquois family of homeobox genes. Irx homeodomain transcription factors are involved in the patterning and development of several tissues. Irx3 is known for its role during embryogenesis in multiple organisms. However, the expression an

SUBMITTER: Scarlett K 

PROVIDER: S-EPMC4358267 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature