Ontology highlight
ABSTRACT:
SUBMITTER: Flynn RL
PROVIDER: S-EPMC4358324 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20150101 6219
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination and is prevalent in a subset of human cancers, yet whether it can be exploited therapeutically remains unknown. Loss of the chromatin-remodeling protein ATRX associates with ALT in cancers. Here, we show that ATRX loss compromises cell-cycle regulation of the telomeric noncoding RNA TERRA and leads to persistent association of replication p ...[more]