Telomerase reverse transcriptase (TERT) rs2736100 polymorphism contributes to increased risk of glioma: evidence from a meta-analysis.

ABSTRACT: The rs2736100 polymorphism in telomerase reverse transcriptase (TERT) gene has been implicated as a risk factor for glioma in previous epidemiological studies. However, the data from these studies were inconclusive for the precise association of TERT rs2736100 with glioma. Here we employed a meta-analysis aiming to evaluate such association. The PubMed, Embase, and Web of Science were systematically searched for eligible studies. The odds ratio (OR) and 95% confidence interval (95% CI) was estimated to assess the strength of this association in fixed or random effects models. A total of 5 studies in 16 articles including 7337 cases and 12062 controls were eventually collected. Our analyses showed that there was a significant association between TERT rs2736100 polymorphism and glioma in all

SUBMITTER: Peng Z 

PROVIDER: S-EPMC4358468 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature