Genetic association between leptin-2548G/A polymorphism and risk of cancer: a meta analysis.

ABSTRACT:

Objective

Abundance of evidence implicated that leptin may play a decisive role in cancer occurrence, but the reported results varied across the individually published studies. The objective of this study is to access to what extent the extensively studied -2548G/A polymorphism of LEP gene acts on the onset of multiple cancers.

Methods

Eligible studies included in this meta-analysis were identified electronically in PubMed and Embase, and manually in relevant literature. Crude odds ratio (OR) with corresponding 95% confidence interval (CI) was calculated to estimate the risk of cancer associated with the -2548G/A polymorphism.

Results

12 association studies with a total of 5,618 cancer cases and 6,509 healthy controls were pooled into this meta-analysis. The results r

SUBMITTER: Liu Y 

PROVIDER: S-EPMC4358471 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature