Association between CTLA-4 rs231775 polymorphism and risk of colorectal cancer: a meta analysis.

ABSTRACT:

Objective

Many previous studies that examined the association between CTLA-4 rs231775 polymorphism and CRC risk have produced inconsistent results. In this study, a meta-analysis was performed to systematically summarize the possible association.

Methods

We identified relevant studies using PubMed, Embase, and China National Knowledge Infrastructure literature databases. Eligible studies were selected using specific criteria. Data were extracted independently by two authors. The pooled OR with 95% CI was estimated by applying the fixed-effects model to examine the association of interest.

Results

Eight studies were identified for the meta-analysis. In overall analysis, we observed an significantly increased CRC risk attributed to the AG genotype as compared to the AA

SUBMITTER: Wang L 

PROVIDER: S-EPMC4358495 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature