Association between regulator of telomere elongation helicase 1 polymorphism and susceptibility to glioma.

ABSTRACT:

Background

Glioma is the most devastating type of malignant brain tumors in adults. Genetic factors play important roles in the pathogenesis of glioma. In recent years, some studies found that there were significant association between regulator of telomere elongation helicase 1 rs6010620 polymorphism and glioma susceptibility, however, the results were controversial. The aim of this study was to obtain a more exact estimation of the association between regulator of telomere elongation helicase 1 rs6010620 polymorphism and glioma through a meta-analysis.

Methods

The meta-analysis included 19 published case-control studies involving 8541 cases and 14226 controls. The included papers were searched from PubMed and Embase database. Odds ratio (OR) with 95% confidence interval (9

SUBMITTER: Pei S 

PROVIDER: S-EPMC4358500 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature