A common genetic variant as an effect modifier for primary angle closure glaucoma.

ABSTRACT:

Background

Epidemiological studies provide evidence of a genetic basis for primary angle closure glaucoma (PACG), and genome-wide association studies (GWAS) have identified various candidate genes as susceptibility loci. However, different results produced by previous studies make the role of a common genetic variant in the COL11A1 gene (rs3753841) remains elusive. Thus, we carried out a meta-analysis, attempting to determine the association of rs3753841 with PACG.

Methods

Potentially relevant studies were identified by systematical computer-based searches. Selection of eligible studies was undertaken by two investigators according to inclusion criteria. The DerSimonian and Laird's method was performed to estimate pooled odds ratios (risk of PACG) under distinct genetic mode

SUBMITTER: Bai H 

PROVIDER: S-EPMC4358525 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature