Role of β-isomerized C-terminal telopeptides (β-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as osteosarcoma biomarkers.

ABSTRACT:

Introduction

Few serum markers are valid and useful for the diagnosis or therapeutic effect monitoring of osteosarcoma. This study aimed to investigate the role of β-isomerized C-terminal telopeptides (β-CTx) and total procollagen type 1 amino-terminal propeptide (tP1NP) as serological biomarkers for osteosarcoma patients.

Materials and methods

A total of 48 patients with osteosarcoma and 55 healthy volunteers were investigated. Serum β-CTx and tP1NP levels were measured by electrochemiluminescence immunoassay. Data were analyzed by t test with Walth's correction and receiver operating characteristic (ROC) curve analysis.

Results

The baseline levels of β-CTx and tP1NP were found to be significantly higher in patients with osteosarcoma than the healthy volunteers. The

SUBMITTER: Hu T 

PROVIDER: S-EPMC4358526 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature