Positive MACC1 expression correlates with invasive behaviors and postoperative liver metastasis in colon cancer.

ABSTRACT:

Objective

Metastasis-associated in colon cancer-1 (MACC1), a new gene associated with primary and metastatic colon cancer, promotes tumor cell growth as well as the development of distant metastasis. The aim of this study is to investigate the expression of MACC1 protein in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis.

Materials and methods

Expression of MACC1 protein was detected immunohistochemically in paraffin-embedded specimens of 96 cases of colon cancer. Relationship between MACC1 protein expression and clinicopathological parameters, postoperative liver metastasis were analyzed.

Results

Immunohistochemistry examination showed that MACC1 protein expression was significantly more abundant in colon cancer

SUBMITTER: Ge Y 

PROVIDER: S-EPMC4358553 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature