The PPARγ2 Pro12Ala variant is protective against progression of nephropathy in people with type 2 diabetes.

ABSTRACT:

Objective

Cross-sectional studies suggest the association between diabetic nephropathy and the PPARγ2 Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ2 (PPARγ2). Prospective data are limited to microalbuminuria and no information on renal function is available to date. The present study evaluates the association between the Pro12Ala polymorphism of PPARγ2 and the progression of albuminuria and decay in glomerular filtration rate (GFR) in type 2 diabetes.

Patients and measurements

We studied 256 patients with an average 5-year follow-up. Among others, urinary albumin excretion rate (UAER) was measured on spot sample, GFR was estimated with the CKD-EPI Equation.

Results

Baseline UAER and GFR were similar for carriers or non-carriers of the polym

SUBMITTER: Lapice E 

PROVIDER: S-EPMC4358785 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature