RSV vaccine-enhanced disease is orchestrated by the combined actions of distinct CD4 T cell subsets.

ABSTRACT: There is no currently licensed vaccine for respiratory syncytial virus (RSV) despite being the leading cause of lower respiratory tract infections in children. Children previously immunized with a formalin-inactivated RSV (FI-RSV) vaccine exhibited enhanced respiratory disease following natural RSV infection. Subsequent studies in animal models have implicated roles for CD4 T cells, eosinophils and non-neutralizing antibodies in mediating enhanced respiratory disease. However, the underlying immunological mechanisms responsible for the enhanced respiratory disease and other disease manifestations associated with FI-RSV vaccine-enhanced disease remain unclear. We demonstrate for the first time that while CD4 T cells mediate all aspects of vaccine-enhanced disease, distinct CD4 T cell subset

SUBMITTER: Knudson CJ 

PROVIDER: S-EPMC4358888 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature