Effects of white matter microstructure on phase and susceptibility maps.

ABSTRACT:

Purpose

To investigate the effects on quantitative susceptibility mapping (QSM) and susceptibility tensor imaging (STI) of the frequency variation produced by the microstructure of white matter (WM).

Methods

The frequency offsets in a WM tissue sample that are not explained by the effect of bulk isotropic or anisotropic magnetic susceptibility, but rather result from the local microstructure, were characterized for the first time. QSM and STI were then applied to simulated frequency maps that were calculated using a digitized whole-brain, WM model formed from anatomical and diffusion tensor imaging data acquired from a volunteer. In this model, the magnitudes of the frequency contributions due to anisotropy and microstructure were derived from the results of the tissue exper

SUBMITTER: Wharton S 

PROVIDER: S-EPMC4359018 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature