Determination of receptor specificities for whole influenza viruses using multivalent glycan arrays.

ABSTRACT: Influenza viruses bind to mucosal glycans to gain entry into a host organism and initiate infection. The target glycans are often displayed in multivalent arrangements on proteins; however, how glycan presentation influences viral specificity is poorly understood. Here, we report a microarray platform approximating native glycan display to facilitate such studies.

SUBMITTER: Huang ML 

PROVIDER: S-EPMC4359031 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature