Second-generation antipsychotics and neuroleptic malignant syndrome: systematic review and case report analysis.

ABSTRACT:

Background

Neuroleptic malignant syndrome (NMS) is a rare, severe, idiosyncratic adverse reaction to antipsychotics. Second-generation antipsychotics (SGAs) were originally assumed to be free from the risk of causing NMS, however several cases of NMS induced by SGAs (SGA-NMS) have been reported.

Objectives

The aim of this study was to systematically review available studies and case reports on SGA-NMS and compare the presentation of NMS induced by different SGAs.

Data sources

Citations were retrieved from PubMed up to November 2013, and from reference lists of relevant citations.

Study eligibility criteria

Eligibility criteria included (a) primary studies reporting data on NMS, with at least 50 % of the sample receiving SGAs; or (b) case reports and case review

SUBMITTER: Belvederi Murri M 

PROVIDER: S-EPMC4359181 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature