Androgen receptors beyond prostate cancer: an old marker as a new target.

ABSTRACT: Androgen receptors (ARs) play a critical role in the development of prostate cancer. Targeting ARs results in important salutary effects in this malignancy. Despite mounting evidence that ARs also participate in the pathogenesis and/or progression of diverse tumors, exploring the impact of hormonal manipulation of these receptors has not been widely pursued beyond prostate cancer. This review describes patterns of AR expression in a spectrum of cancers, and the potential to exploit this knowledge in the clinical therapeutic setting.

SUBMITTER: Munoz J 

PROVIDER: S-EPMC4359241 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature