Relationship between CYP17A1 genetic polymorphism and coronary artery disease in a Chinese Han population.

ABSTRACT:

Background

CYP17A1 gene encodes P450c17 proteins, which is a key enzyme that catalyzes the formation of sex hormones. Many clinical studies showed that sex hormones levels play an important role in the pathogenesis of coronary artery disease (CAD). However, the relationship between CYP17A1 genetic polymorphisms and CAD remains unclear. The aim of this study was to investigate the association of CYP17A1 genetic polymorphisms with CAD in a Han population of China.

Methods

A total of 997 people include 490 patients and 507 controls were selected for the present study. Five single-nucleotide polymorphisms (SNPs) (rs4919686, rs1004467, rs4919687, rs10786712, and rs2486758) were genotyped by using the real-time PCR (TaqMan) method.

Results

For men, the rs10786712 was found

SUBMITTER: Dai CF 

PROVIDER: S-EPMC4359393 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature