A genome-wide pleiotropy scan for prostate cancer risk.

ABSTRACT:

Background

No single-nucleotide polymorphisms (SNPs) specific for aggressive prostate cancer have been identified in genome-wide association studies (GWAS).

Objective

To test if SNPs associated with other traits may also affect the risk of aggressive prostate cancer.

Design, setting, and participants

SNPs implicated in any phenotype other than prostate cancer (p≤10(-7)) were identified through the catalog of published GWAS and tested in 2891 aggressive prostate cancer cases and 4592 controls from the Breast and Prostate Cancer Cohort Consortium (BPC3). The 40 most significant SNPs were followed up in 4872 aggressive prostate cancer cases and 24,534 controls from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL

SUBMITTER: Panagiotou OA 

PROVIDER: S-EPMC4359641 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature