Axonal transport cargo motor count versus average transport velocity: is fast versus slow transport really single versus multiple motor transport?

ABSTRACT: Cargos have been observed exhibiting a "stop-and-go" behavior (i.e. cargo "pause"), and it has generally been assumed that these multi-second pauses can be attributed to equally long pauses of cargo-bound motors during motor procession. We contend that a careful examination of the isolated microtubule experimental record does not support motor pauses. Rather, we believe that the data suggests that motor cargo complexes encounter an obstruction that prevents procession, eventually detach and reattach, with this obstructed-detach-reattach sequence being observed in axon as a "pause." Based on this, along with our quantitative evidence-based contention that slow and fast axonal transport are actually single and multi-motor transport, we have developed a cargo level motor model capable of exhi

SUBMITTER: Lee RH 

PROVIDER: S-EPMC4359950 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature