Genomic analysis of metastatic cutaneous squamous cell carcinoma.

ABSTRACT:

Purpose

A rare 5% of cutaneous squamous cell carcinomas (cSCC) metastasize, lack FDA-approved therapies, and carry a poor prognosis. Our aim was to identify recurrent genomic alterations in this little-studied population of metastatic cSCCs.

Experimental design

We performed targeted sequencing of 504 cancer-associated genes on lymph node metastases in 29 patients with cSCC and identified mutations and somatic copy-number alterations associated with metastatic cSCC. We determined significantly mutated, deleted, and amplified genes and associated genomic alterations with clinical variables.

Results

The cSCC genome is heterogeneous with widely varying numbers of genomic alterations and does not appear to be associated with human papillomavirus. We found previously identi

SUBMITTER: Li YY 

PROVIDER: S-EPMC4359951 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature