Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism.

ABSTRACT:

Introduction

Monoallelic expression of imprinted genes is necessary for placental development and normal fetal growth. Differentially methylated domains (DMDs) largely determine the parental-specific monoallelic expression of imprinted genes. Maternally derived DNA (cytosine-5-) -methyltransferase 1o (DNMT1o) maintains DMDs during the eight-cell stage of development. DNMT1o-deficient mouse placentas have a generalized disruption of genomic imprints. Previous studies have demonstrated that DNMT1o deficiency alters placental morphology and broadens the embryonic weight distribution in late gestation. Lipids are critical for fetal growth. Thus, we assessed the impact of disrupted imprinting on placental lipids.

Methods

Lipids were quantified from DNMT1o-deficient mouse placenta

SUBMITTER: Himes KP 

PROVIDER: S-EPMC4359963 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature