Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks.

ABSTRACT: Tumor cell invasion through the stromal extracellular matrix (ECM) is a key feature of cancer metastasis, and understanding the cellular mechanisms of invasive migration is critical to the development of effective diagnostic and therapeutic strategies. Since cancer cell migration is highly adaptable to physiochemical properties of the ECM, it is critical to define these migration mechanisms in a context-specific manner. Although extensive work has characterized cancer cell migration in two- and three-dimensional (3D) matrix environments, the migration program employed by cells to move through native and cell-derived microtracks within the stromal ECM remains unclear. We previously reported the development of an in vitro model of patterned type I collagen microtracks that enable matrix meta

SUBMITTER: Carey SP 

PROVIDER: S-EPMC4360026 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature