Modulation of peripheral chemoreflex by neurohumoral adaptations after kidney transplantation.

ABSTRACT:

Background

Peripheral chemoreceptors residing predominantly in the carotid body monitor changes in arterial blood oxygen and are mechanistically linked to the cardiorespiratory control by the autonomic nervous system. Enhanced sympathetic activation is common in end-stage renal disease and kidney transplantation has been shown to improve cardiorespiratory reflex measures of autonomic function.

Objective

The aim of the present study was to test whether improvement in renal function following kidney transplantation is related to an improvement in chemosensory function.

Methods and results

We compared hyperoxic chemoreflex sensitivity (CHRS) in patients after renal transplantation (RTX) to that in patients on maintenance hemodialysis (HD), and that of age- and gender-mat

SUBMITTER: Rassaf T 

PROVIDER: S-EPMC4360365 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature