Characterization of regulatory sequences in alternative promoters of hypermethylated genes associated with tumor resistance to cisplatin.

ABSTRACT: The development of cisplatin resistance in human cancers is controlled by multiple genes and leads to therapeutic failure. Hypermethylation of specific gene promoters is a key event in clinical resistance to cisplatin. Although the usage of multiple promoters is frequent in the transcription of human genes, the role of alternative promoters and their regulatory sequences have not yet been investigated in cisplatin resistance genes. In a new approach, we hypothesized that human cancers exploit the specific transcription factor-binding sites (TFBS) and CpG islands (CGIs) located in the alternative promoters of certain genes to acquire platinum drug resistance. To provide a useful resource of regulatory elements associated with cisplatin resistance, we investigated the TFBS and CGIs in 48 alt

SUBMITTER: Ibrahim-Alobaide MA 

PROVIDER: S-EPMC4360857 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature