Secretion of salivary statherin is compromised in uncontrolled diabetic patients.

ABSTRACT:

Background

Statherin is an important salivary protein for maintaining oral health. The purpose of the current study was to determine if differences in statherin levels exist between diabetic and healthy subjects.

Methods

A total of 48 diabetic and healthy controls were randomly selected from a community-based database. Diabetic subjects (n=24) had fasting glucose levels >180 mg/dL, while controls (n=24) had levels <110 mg/dL. Parotid saliva (PS) and sublingual/submandibular saliva (SS) were collected and salivary flow rates determined. Salivary statherin levels were determined by densitometry of Western blots. Blood hemoglobin A1c (HbA1c) and total protein in saliva were also obtained.

Results

SS, but not PS, salivary flow rate and total protein in diabetics were sign

SUBMITTER: Izumi M 

PROVIDER: S-EPMC4360915 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature